http://journals.sagepub.com/doi/10.1177/1559325818789840
Edward J. Calabrese, , Jaap C. Hanekamp, , and Dima Yazji Shamoun
Abstract
This article strongly supports the Environmental Protection Agency proposal to make significant changes in their cancer risk
assessment principles and practices by moving away from the use of the linear nonthreshold (LNT) dose–response as the default
model. An alternate approach is proposed based on model uncertainty which integrates the most scientifically supportable
features of the threshold, hormesis, and LNT models to identify the doses that optimize population-based responses (ie, maximize
health benefits/minimize health harm). This novel approach for cancer risk assessment represents a significant improvement to
the current LNT default method from scientific and public health perspectives.