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The impact of dose rate on the linear no threshold hypothesis

The impact of dose rate on the linear no threshold hypothesis

by admin | Jul 18, 2019 | LNT Hypothesis

Research Article Summary • Central focus:This article explores how radiation dose rate—not just total dose—affects biological response and challenges assumptions of the Linear No-Threshold (LNT) hypothesis, which ignores dose rate in driving risk estimates. • Dose...
Re-evaluation of the linear no-threshold (LNT) model using new paradigms and modern molecular studies

Re-evaluation of the linear no-threshold (LNT) model using new paradigms and modern molecular studies

by admin | Jul 18, 2019 | Featured Articles, LNT Hypothesis

Research Article Summary • Primary focus:This article investigates how cellular adaptive responses influence the relationship between low-dose ionizing radiation and biological effects, questioning whether a strictly proportional relationship (as assumed in the Linear...
Why toxicologists resisted and radiation geneticists supported EPA’S adoption of LNT for cancer risk assessment

Why toxicologists resisted and radiation geneticists supported EPA’S adoption of LNT for cancer risk assessment

by admin | Jul 8, 2019 | LNT Hypothesis

https://www.sciencedirect.com/science/article/pii/S0009279719308634?via%3Dihub Abstract The linear non-threshold (LNT) dose response model for cancer risk assessment has been a controversial concept since its initial proposal during the 1930s. It was long advocated by...
Muller’s Nobel Prize data: Getting the dose wrong and its significance

Muller’s Nobel Prize data: Getting the dose wrong and its significance

by admin | Jul 8, 2019 | LNT Hypothesis

https://www.sciencedirect.com/science/article/pii/S0013935119303251?via%3Dihub This paper evaluates the significant historical paper of Muller and Mott-Smith (1930), which successfully disputed the proposal of Olson and Lewis (1928) that background ionizing radiation...
Assessing the Scientific Basis of the Linear No Threshold (LNT) Model with Threshold Models for Cancer Risk Assessment of Radiation and Chemicals

Assessing the Scientific Basis of the Linear No Threshold (LNT) Model with Threshold Models for Cancer Risk Assessment of Radiation and Chemicals

by admin | Jun 28, 2019 | Featured Articles, LNT Hypothesis

Research Article Summary • Scope of the special issue:This special issue of Chemico-Biological Interactions brings together multiple articles examining how low-dose chemical and physical stressors, including ionizing radiation, interact with biological systems. The...
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