Why toxicologists resisted and radiation geneticists supported EPA’S adoption of LNT for cancer risk assessment

by admin | Jul 8, 2019 | LNT Hypothesis

https://www.sciencedirect.com/science/article/pii/S0009279719308634?via%3Dihub Abstract The linear non-threshold (LNT) dose response model for cancer risk assessment has been a controversial concept since its initial proposal during the 1930s. It was long advocated by...

Muller’s Nobel Prize data: Getting the dose wrong and its significance

by admin | Jul 8, 2019 | LNT Hypothesis

https://www.sciencedirect.com/science/article/pii/S0013935119303251?via%3Dihub This paper evaluates the significant historical paper of Muller and Mott-Smith (1930), which successfully disputed the proposal of Olson and Lewis (1928) that background ionizing radiation...

Assessing the Scientific Basis of the Linear No Threshold (LNT) Model with Threshold Models for Cancer Risk Assessment of Radiation and Chemicals

by admin | Jun 28, 2019 | Featured Articles, LNT Hypothesis

Research Article Summary • Scope of the special issue:This special issue of Chemico-Biological Interactions brings together multiple articles examining how low-dose chemical and physical stressors, including ionizing radiation, interact with biological systems. The...

Molecular Bioligy, Epidemiology and the Demise of the LNT Hypotesis

by admin | Jun 24, 2019 | LNT Hypothesis

Research Article Summary • Primary focus:This article examines cellular and biochemical responses to very low doses of ionizing radiation, exploring whether simple linear extrapolation from high-dose effects reflects true biological behavior at low doses. • Biological...

Interests, Bias, and Consensus in Science and Regulation

by admin | Jun 11, 2019 | Fear, Uncertainty and Doubt, Featured Articles, LNT Hypothesis

Research Article Summary • Main topic:This article examines how low-dose ionizing radiation affects biological systems, with a focus on evidence challenging the traditional assumption that risk increases linearly with dose starting from zero. It reviews cellular and...

Linear No-threshold (LNT) vs. Hormesis Paradigms, Assumptions, and Mathematical Conventions that Bias the Conclusions in Favor of LNT and Against hormesis

by admin | May 22, 2019 | Hormesis, LNT Hypothesis

https://journals.lww.com/health-physics/Fulltext/2019/06000/Linear_No_threshold__LNT__vs__Hormesis__Paradigms,.7.aspx The linear no-threshold assumption misunderstands the complex multiphasic biological response to ionizing radiation, focusing solely on the initial...