This paper demonstrates that the dissertation research of Ray-Chaudhuri (1939, 1944) that was used by Hermann
Muller to support his radiation induced gene mutation hypothesis and linear non-threshold (LNT) dose response
model during his Nobel Prize Lecture is “uninterpretable” with respect to these issues. The research failed to
include essential research design information, resulting in reporting flaws that have never been previously
identified. These observations are historically important because this dissertation was used to blunt powerful
criticism of Muller’s gene mutation research and strongly promoted his advocacy of the LNT model in radiation
risk assessment.